This hearty meatloaf combines rich bison with smoky bacon and a spicy kick from green chiles, making it a flavorful twist on a classic favorite. It’s perfect for a cozy dinner that’s both comforting and exciting.
Prep Time
10 min
Cook Time
1 hr 45 min
Total Time
1 hr 55 min
Difficulty
Hard
Ingredients
1 ½ pounds ground bison
1 cup milk
½ cup Italian seasoned bread crumbs
½ cup chopped green chile peppers
½ cup bacon bits
1 large egg, beaten
1 ½ teaspoons liquid smoke flavoring
1 teaspoon onion powder
½ teaspoon dry mustard
¼ teaspoon garlic powder
¼ teaspoon ground sage
¾ cup barbeque sauce, or more to taste
Why This Dish Is Worth Trying
This dish combines rich, hearty flavors with a smoky kick from the bacon and green chiles. It’s a great way to enjoy bison, which is leaner and more flavorful than traditional beef. The mix of ingredients keeps the meatloaf moist and satisfying.
Cooking Secrets
- Use a meat thermometer to ensure the meatloaf is cooked through without drying out.
- Let the meatloaf rest for 10 minutes after baking to help it hold together when slicing.
- If you like extra spice, add a pinch of cayenne pepper or diced jalapeños to the mix.
Directions
Heat your oven to 350°F (175°C). In a large bowl, combine the ground bison with milk, bread crumbs, chopped green chiles, bacon bits, egg, liquid smoke, onion powder, dry mustard, garlic powder, and ground sage. Use your hands to mix everything together well. Press the mixture evenly into a 9x5-inch loaf pan. Spread a generous layer of barbecue sauce over the top. Pop it in the oven and bake until the meatloaf is cooked through and no longer pink in the center, which should take about 1 hour and 45 minutes. Let it rest for a few minutes before slicing and serving.
How To Enjoy This Dish
Serve this with creamy mashed potatoes or roasted vegetables to balance the smoky and spicy flavors. A fresh green salad or cornbread also pairs well to round out the meal.
Keeping Leftovers Fresh
Store leftovers in an airtight container in the refrigerator for up to 3 days. You can also freeze slices wrapped tightly in plastic wrap and foil for up to 2 months. Reheat gently in the oven or microwave to keep the texture tender.
Frequently Asked Questions
Can I use ground beef instead of bison?
Yes, ground beef can be used as a substitute with similar results.
How do I know when the meatloaf is fully cooked?
It’s done when the internal temperature reaches 160°F and the center is no longer pink.
Can I make this recipe ahead of time?
Yes, you can prepare it a day ahead and refrigerate before baking.
What can I use if I don’t have liquid smoke?
You can omit it or add a small amount of smoked paprika for a similar flavor.
Is it possible to freeze the meatloaf?
Yes, wrap it tightly and freeze before baking; thaw in the fridge before cooking.
Can I use fresh green chiles instead of canned?
Fresh green chiles work well; just chop and measure the same amount.
What side dishes go well with this meatloaf?
Mashed potatoes, roasted vegetables, or a simple salad are great choices.
How do I prevent the meatloaf from drying out?
Mixing in milk and spreading barbecue sauce on top helps keep it moist.
AM
By Ankit Mehta
Home Cooking Guide
Ankit enjoys creating straightforward recipes with clear steps for stress-free cooking at home.
373
home cooks made it!
Reviews (12)
4.8 out of 5
★★★★★
12 Ratings
5 star
9
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3
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Rate This Recipe
User Reviews
Ahmed
★★★★☆
Mar 14, 2026
The spices and bacon made this really tasty, though I added a bit more chile for extra heat.
Leila
★★★★★
Mar 04, 2026
I’ve made traditional meatloaf before, but this version with green chiles was a pleasant surprise. The heat level was just right, and the bacon added a nice crunch on top. The texture was tender, and it reheated well the next day. Definitely a new favorite in our house.
Olivia
★★★★★
Mar 01, 2026
So glad I tried this—perfect balance of smoky and spicy, and very satisfying for my family!
Lisa
★★★★☆
Mar 01, 2026
Easy to prepare and packed with flavor—I’ll definitely be making this again soon!
Jeroen
★★★★★
Feb 22, 2026
First time trying bison meatloaf and I was pleasantly surprised. The recipe was easy to follow, and it came out moist with just enough spice from the chiles. I forgot to soak the bread crumbs, but it didn’t affect the texture much. Definitely adding this one to my recipe box.
Emil
★★★★★
Feb 14, 2026
Tried this for the first time last night and wow, it’s delicious. The bacon and chiles made it unique and flavorful. I skipped the extra spices since I wasn’t sure how spicy it’d be, but it was just right. Took about an hour from start to finish, very manageable.
Fatima
★★★★★
Jan 23, 2026
I love how the green chiles give a subtle smokiness without overpowering the bison. The bacon was a nice surprise that added crunch and saltiness. I will definitely keep this recipe in my rotation for guest dinners. Easy to prepare and the leftovers were just as good!
Liam
★★★★☆
Jan 02, 2026
The overall flavor was great, but I think I accidentally added a bit too much seasoning, so it came out a touch salty. Apart from that, the recipe was easy to follow and the mix of bacon and chiles gives it a nice twist. Will try again with less salt.
Linda
★★★★★
Dec 22, 2025
The bacon crisped up just right, and the green chiles gave it a fun, mild heat. Delicious dinner!
David
★★★★★
Dec 16, 2025
This was a great dinner option—rich, hearty, and the bacon made it even better!
Marcus J.
★★★★★
Dec 10, 2025
The combination of smoky bacon and spicy chiles really made this dish pop. Will make again!
Sarah J.
★★★★★
Nov 20, 2025
Loved how the smoky bacon and green chiles added a perfect kick to the meatloaf! Easy to follow.
Nutrition Facts
Calories320
Fat18 g
Carbs8 g
Protein30 g
Fiber2 g
Sugar4 g
Sodium600 mg
Serving Size: 1 slice (1/6 of meatloaf)
*Nutrition values are estimated and may vary depending on ingredient brands, portion sizes, and preparation methods.